Title

Urinary Escherichia Coli Antimicrobial Susceptibility Profiles and their Relationship with Community Antibiotic use in Tasmania, Australia

Document Type

Article

Publication Date

10-2015

Publication Details

This article was originally published as:

Meumann, E. M., Mitchell, B. G., McGregor, A., McBryde, E., & Cooley, L. (2015). Urinary Escherichia coli antimicrobial susceptibility profiles and relationship with community antibiotic use in Tasmania, Australia. International Journal of Antimicrobial Agents, 46(4), 389-393. doi:10.1016/j.ijantimicag.2015.05.015

ISSN: 0924-8579

ANZSRC / FoR Code

060502 Infectious Agents| 110801 Medical Bacteriology| 111002 Clinical Nursing: Primary (Preventative)| 111706 Epidemiology| 111716 Preventive Medicine| 111717 Primary Health Care

Reportable Items

C1

Abstract

This study assessed urinary Escherichia coli antibiotic susceptibility patterns in Tasmania, Australia, and examined their association with community antibiotic use. The susceptibility profiles of all urinary E. coli isolates collected in Tasmania between January 2010 and December 2012 were included. The amount of Pharmaceutical Benefits Scheme (PBS)-subsidised use of amoxicillin, amoxicillin/clavulanic acid (AMC),cefalexin, norfloxacin, ciprofloxacin and trimethoprim was retrieved (at the Tasmanian population level)and the number of defined daily doses per 1000 population per day in Tasmania for these antibiotics was calculated for each month during the study period. Antimicrobial susceptibility data were assessed for changes over time in the 3-year study period. Antimicrobial use and susceptibility data were assessed for seasonal differences and lag in resistance following antibiotic use. Excluding duplicates, 27 775 E. coli isolates were included. Resistance levels were low; 35% of isolates were non-susceptible to amoxicillin,14% were non-susceptible to trimethoprim and

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