Title

Access to the Parent Tetrakis(pyridine)gold(III) Trication, Facile Formation of Rare Au(III) Terminal Hydroxides, and Preliminary Studies of Biological Properties

Document Type

Article

Publication Date

3-2016

Publication Details

This article was originally published as:

Corbo, R., Ryan, G. F., Haghighatbin, M. A., Hogan, C. F., Wilson, D. J.,,, Dutton, J. L. (2016). Access to the parent Tetrakis(pyridine)gold(III) Trication, Facile formation of Rare Au(III) Terminal Hydroxides, and preliminary studies of biological properties. Inorganic Chemistry, 55(6), 2830-2839. doi: 10.1021/acs.inorgchem.5b02667

ISSN:1520-510X

Abstract

In this paper we report on the use of [NO][BF4] to access tricationic tetrakis(pyridine)gold(III) from Au powder, a species inaccessible using the more traditional (tetrahydrothiophene)AuCl route. It is then demonstrated that this family of compounds can be used to access new terminal Au(III) hydroxides, a challenging class of compounds, and the first crystallographically characterized examples employing bidentate ligands. Finally, preliminary biological studies indicate good activity for derivatives featuring polydentate ligands against the HeLa and PC3 cell lines but also strong inhibition of primary HUVEC cells.

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David Wilson is affiliated with Avondale College as a Conjoint Senior Lecturer.

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