Quantitation of NAD+: Why Do We Need to Measure it?
| avondale-bepress.context-key | 13665246 | |
| avondale-bepress.submission-path | nh_papers/178 | |
| avondale.affiliate | Grant, Ross | |
| avondale.department | Lifestyle Medicine and Health Research Centre | |
| avondale.faculty | Nursing | |
| avondale.reporting.version | Published Version | |
| dc.contributor.author | Braidy, Nady | |
| dc.contributor.author | Sachdev, Perminder | |
| dc.contributor.author | Grant, Ross | |
| dc.contributor.author | Clement, James | |
| dc.contributor.author | Liu, Yue | |
| dc.date.accessioned | 2023-11-01T00:27:57Z | |
| dc.date.available | 2023-11-01T00:27:57Z | |
| dc.date.issued | 2018-12-01 | |
| dc.date.submitted | 2019-01-22T19:08:07Z | |
| dc.description.abstract | <p><strong>Background: </strong></p> <p><strong></strong>Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is currently investigated as an important target to extend lifespan and health span. Age-related NAD+ depletion due to the accumulation of oxidative stress is associated with reduced energy production, impaired DNA repair and genomic instability.</p> <p><strong>Scope of review:</strong> NAD+ levels can be elevated therapeutically using NAD+ precursors or through lifestyle modifications including exercise and caloric restriction. However, high amounts of NAD+ may be detrimental in cancer progression and may have deleterious immunogenic roles. <strong></strong></p> <p><strong>Major conclusions:</strong> Standardized quantitation of NAD+ and related metabolites may therefore represent an important component of NAD+ therapy. <strong></strong></p> <p><strong>General significance:</strong> Quantitation of NAD+ may serve dual roles not only as an ageing biomarker, but also as a diagnostic tool for the prevention of malignant disorders.</p> | |
| dc.identifier.citation | <p>Liu, Y., Clement, J., Grant, R., Sachdev, P., & Braidy, N. (2018). Quantitation of NAD+: Why do we need to measure it? <em>Biochimica et Biophysica Acta (BBA) - General Subjects, 1862</em>(12), 2527-2532. doi: 10.1016/j.bbagen.2018.07.023</p> | |
| dc.identifier.doi | https://doi.org/10.1016/j.bbagen.2018.07.023 | |
| dc.identifier.issn | 0304-4165 | |
| dc.identifier.uri | https://research.avondale.edu.au/handle/1897/13665246 | |
| dc.language.iso | en_us | |
| dc.provenance | <p>This article was originally published as:</p> <p>Liu, Y., Clement, J., Grant, R., Sachdev, P., & Braidy, N. (2018). Quantitation of NAD+: Why do we need to measure it? <em>Biochimica et Biophysica Acta (BBA) - General Subjects, 1862</em>(12), 2527-2532. doi: 10.1016/j.bbagen.2018.07.023</p> <p>ISSN: 0304-4165</p> | |
| dc.relation.ispartof | Biochimica et Biophysica Acta (BBA) - General Subjects | |
| dc.rights | <p>Due to copyright restrictions this article is unavailable for download.</p> <p>This article may be accessed from the publisher <a href="https://doi.org/10.1016/j.bbagen.2018.07.023">here</a>.</p> <p>Copyright © 2018 Published by Elsevier B.V. All rights reserved</p> | |
| dc.subject | NAD+; Nicotinamide; Ageing; Cancer; Biomarker | |
| dc.title | Quantitation of NAD+: Why Do We Need to Measure it? | |
| dc.type | Journal Article |