Synthesis of Substituted 4-(1H-indol-6-yl)-1H-indazoles as Potential PDK1 Inhibitors
| avondale-bepress.context-key | 6907338 | |
| avondale-bepress.submission-path | sci_math_papers/63 | |
| avondale.faculty | Science | |
| avondale.reporting.isPeerReviewed | Peer Reviewed | |
| avondale.reporting.version | Published Version | |
| dc.contributor.author | Abbott, Belinda M. | |
| dc.contributor.author | Wilson, David J. | |
| dc.contributor.author | O'Brien, Nathan J. | |
| dc.contributor.author | Brzozowski, Martin | |
| dc.date.accessioned | 2023-11-01T00:39:24Z | |
| dc.date.available | 2023-11-01T00:39:24Z | |
| dc.date.issued | 2014-01-14 | |
| dc.date.submitted | 2015-03-26T20:54:16Z | |
| dc.description.abstract | <p>The development of a preparative route to a series of novel 4-(1H-indol-6-yl)-1H-indazole compounds as potential PDK1 inhibitors is described. The synthetic strategy centres on the late-stage Suzuki crosscoupling of N-unprotected indazole and indole fragments. The use of a monoligated palladium catalyst system was found to be highly beneficial in the cross-coupling reaction. The indazole and indole fragments were constructed by diazotisation/cyclisation and SNAr/reductive cyclisation sequences, respectively.</p> | |
| dc.identifier.citation | <p>Brzozowski, M., O'Brien, N. J., Wilson, D. J., & Abbott, B. M. (2014). Synthesis of substituted 4-(1H-indol-6-yl)-1H-indazoles as potential PDK1 inhibitors. <em>Tetrahedron, 70</em>(2), 318-326. doi:10.1016/j.tet.2013.11.054</p> | |
| dc.identifier.doi | https://doi.org/10.1016/j.tet.2013.11.054 | |
| dc.identifier.issn | 0040-4020 | |
| dc.identifier.uri | https://research.avondale.edu.au/handle/1897/06907338 | |
| dc.language.iso | en_us | |
| dc.provenance | <p>This article was originally published as:</p> <p>Brzozowski, M., O'Brien, N. J., Wilson, D. J., & Abbott, B. M. (2014). Synthesis of substituted 4-(1H-indol-6-yl)-1H-indazoles as potential PDK1 inhibitors. <em>Tetrahedron, 70</em>(2), 318-326. doi:10.1016/j.tet.2013.11.054</p> <p>ISSN:0040-4020</p> | |
| dc.relation.ispartof | Tetrahedron | |
| dc.rights | <p>Due to copyright restrictions this article is unavailable for download.</p> <p>Copyright © 2014 Published by Elsevier Ltd. All rights reserved.</p> | |
| dc.subject | 3-Phosphoinositide-dependent kinase 1 (PDK1) | |
| dc.subject | 4-(1H-Indol-6-yl)-1H-indazole | |
| dc.subject | Inhibitor | |
| dc.subject | Suzuki cross-coupling | |
| dc.title | Synthesis of Substituted 4-(1H-indol-6-yl)-1H-indazoles as Potential PDK1 Inhibitors | |
| dc.type | Journal Article |