Self-Assembled Nanomaterials Based on Beta (β3) Tetrapeptides
| avondale-bepress.context-key | 9759142 | |
| avondale-bepress.submission-path | sci_math_papers/83 | |
| avondale.faculty | Science | |
| avondale.reporting.isPeerReviewed | Peer Reviewed | |
| avondale.reporting.version | Published Version | |
| dc.contributor.author | Mechler, Adam | |
| dc.contributor.author | Perimutter, Patrick | |
| dc.contributor.author | Aguilar, Marie-Isabel | |
| dc.contributor.author | Del Borgo, Mark | |
| dc.contributor.author | Adda, Christopher G. | |
| dc.contributor.author | Wilson, David J. | |
| dc.contributor.author | Hinds, Mark G. | |
| dc.contributor.author | Seoudi, Rania S. | |
| dc.date.accessioned | 2023-11-01T00:24:42Z | |
| dc.date.available | 2023-11-01T00:24:42Z | |
| dc.date.issued | 2016-04-01 | |
| dc.date.submitted | 2017-02-27T21:22:17Z | |
| dc.description.abstract | <p><em>β</em> 3-amino acid based polypeptides offer a unique starting material for the design of self-assembled nanostructures such as fibres and hierarchical dendritic assemblies, due to their well-defined helical geometry in which the peptide side chains align at 120° due to the 3.0–3.1 residue pitch of the helix. In a previous work we have described the head-to-tail self-assembly of N-terminal acetylated <em>β</em> 3-peptides into infinite helical nanorods that was achieved by designing a bioinspired supramolecular self-assembly motif. Here we describe the effect of consecutively more polar side chains on the self-assembly characteristics of <em>β</em> 3-tetrapeptides Ac-<em>β</em> 3Ala-<em>β</em> 3Leu-<em>β</em> 3Ile-<em>β</em> 3Ala (Ac-β3[ALIA]), Ac-<em>β</em>3Ser-<em>β</em> 3Leu-<em>β</em> 3Ile-<em>β</em> 3Ala (Ac-β3[SLIA]) and Ac-<em>β</em> 3Lys-<em>β</em> 3Leu-<em>β</em> 3Ile-<em>β</em> 3Glu (Ac-β3[KLIE]). <em>β</em> 3-tetrapeptides complete 1 1/3 turns of the helix: thus in the oligomeric form the side chain positions shift 120° with each added monomer, forming a regular periodic pattern along the nanorod. Dynamic light scattering (DLS) measurements confirmed that these peptides self-assemble even in highly polar solvents such as water and DMSO, while diffusion-ordered NMR spectroscopy revealed the presence of a substantial monomeric population. Temperature dependence of the size distribution in DLS measurements suggests a dynamic equilibrium between monomers and oligomers. Solution casting produced distinct fibrillar deposits after evaporating the solvent. In the case of the apolar Ac-<em>β</em> 3[ALIA] the longitudinal helix morphology gives rise to geometrically defined (~70°) junctions between fibres, forming a mesh that opens up possibilities for applications e.g. in tissue scaffolding. The deposits of polar Ac-<em>β</em> 3[SLIA] and Ac-<em>β</em> 3[KLIE] exhibit fibres in regular parallel alignment over surface areas in the order of 10 <em>μ</em>m.</p> | |
| dc.identifier.citation | <p>Seoudi, R. S., Hinds, M. G., Wilson, D. J., Adda, C. G., Del Borgo, M...Mechler, A. (2016). Self-assembled nanomaterials based on beta (β3 ) tetrapeptides. <em>Nanotechnology, 27</em>(13), 135606. doi:10.1088/0957-4484/27/13/135606</p> | |
| dc.identifier.doi | https://doi.org/10.1088/0957-4484/27/13/135606 | |
| dc.identifier.issn | 1361-6528 | |
| dc.identifier.uri | https://research.avondale.edu.au/handle/1897/09759142 | |
| dc.language.iso | en_us | |
| dc.provenance | <p>This article was originally published as:</p> <p>Seoudi, R. S., Hinds, M. G., Wilson, D. J., Adda, C. G., Del Borgo, M...Mechler, A. (2016). Self-assembled nanomaterials based on beta (β3 ) tetrapeptides. <em>Nanotechnology, 27</em>(13), 1-9. doi: 10.1088/0957-4484/27/13/135606</p> <p>ISSN: 0957-4484</p> | |
| dc.relation.ispartof | Nanotechnology | |
| dc.rights | <p>Due to copyright restrictions this article is unavailable for download.</p> <p>Copyright © 2016 IOP Publishing Ltd</p> | |
| dc.subject | bioinspired fibrous materials | |
| dc.subject | supramolecular self-assembly | |
| dc.subject | atomic force microscopy | |
| dc.subject | bottom-up nanofabrication | |
| dc.title | Self-Assembled Nanomaterials Based on Beta (β3) Tetrapeptides | |
| dc.type | Journal Article |