The Effect of a Low-Fat, Plant-Based Lifestyle Intervention (CHIP) on Serum HDL Subfraction Levels - A Cohort Study

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This conference proceeding was originally published as:

Kent, L., Grant, R., Watts, G., Morton, D. P., Ward, E. (2017, June). The effect of a low-fat, plant-based lifestyle intervention (CHIP) on serum hdl subfraction levels – A cohort study. Paper presented at the Nutrition Society of Australia 40th Annual Scientific Meeting, Melbourne, Australia. Abstract retrieved from http://dx.doi.org/10.1016/j.jnim.2017.04.170

ISSN: 2352-3859


111104 Public Nutrition Intervention

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Background/Aims: Low levels of HDL are considered an important risk

factor for CVD. Lifestyle interventions promoting a low-fat, plant-based

eating pattern appear to reduce cardiovascular risk while paradoxically

also reducing HDL levels. Recent studies have shown HDL to comprise a

range of subfractions, but the role these play in ameliorating the risk of

CVD is unclear. The purpose of this study was to characterize potential

differences in changes in HDL subfractions in individuals participating in

the Complete Health Improvement Program (CHIP) lifestyle intervention.

Methods: Individuals participating in a CHIP intervention were assessed at

baseline and 30 days for changes in BMI, BP, lipid profile, including large-,

intermediate- and small-HDL subfractions, and fasting plasma glucose.

Only individuals (n ¼ 22; mean ± SD age: 55.4 ± 16.3 years; 45.5% men)

where HDL decreased were included in the analyses. The extent of change

in each measure was assessed using paired t-tests.

Results: In 30 days, all biometrics, including HDL subfractions significantly

decreased, except for triglycerides which did not change. The decrease in

small HDL was at least two-times greater than large or intermediate-HDL

(22.7%, 10.0%, 8.3%, respectively). Intermediate-HDL was the most abundant

subfraction at baseline and 30-days.

Conclusions: Levels of all HDL subfractions decreased in response to the

adoption of a whole-foods, plant-based diet, along with other indicators of

cardiovascular risk. Additional research is required to elucidate the reasons

through which lifestyle therapies remodel the HDL particle and how this

impacts the functional properties of HDL and vascular disease risk.

Funding source(s): N/A


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This is an Elsevier open access article made available under the terms of the Creative Commons License https://creativecommons.org/licenses/by-nc-nd/4.0/