Author Faculty (Discipline)

Nursing

Document Type

Article

Publication Date

11-28-2017

JOURNAL

British Medical Journal (BMJ) Open

VOLUME NUMBER

7

ISSUE NUMBER

11

PAGE NUMBERS

e018871

ISSN

2044-6055

Embargo Period

12-5-2017

ANZSRC / FoR Code

111002 Clinical Nursing: Primary (Preventative)| 111705 Environmental and Occupational Health and Safety| 111716 Preventive Medicine

Avondale Research Centre

Lifestyle Research Centre

Reportable Items (HERDC/ERA)

C1

Abstract

Introduction

Despite advances in infection prevention and control, catheter-associated urinary tract infections (CAUTIs) are common and remain problematic. A number of measures can be taken to reduce the risk of CAUTI in hospitals. Appropriate urinary catheter insertion procedures are one such method. Reducing bacterial colonisation around the meatal or urethral area has the potential to reduce CAUTI risk. However, evidence about the best antiseptic solutions for meatal cleaning is mixed, resulting in conflicting recommendations in guidelines internationally. This paper presents the protocol for a study to evaluate the effectiveness (objective 1) and cost-effectiveness (objective 2) of using chlorhexidine in meatal cleaning prior to catheter insertion, in reducing catheter-associated asymptomatic bacteriuria and CAUTI.

Methods and analysis

A stepped wedge randomised controlled trial will be undertaken in three large Australian hospitals over a 32-week period. The intervention in this study is the use of chlorhexidine (0.1%) solution for meatal cleaning prior to catheter insertion. During the first 8 weeks of the study, no hospital will receive the intervention. After 8 weeks, one hospital will cross over to the intervention with the other two participating hospitals crossing over to the intervention at 8-week intervals respectively based on randomisation. All sites complete the trial at the same time in 2018. The primary outcomes for objective 1 (effectiveness) are the number of cases of CAUTI and catheter-associated asymptomatic bacteriuria per 100 catheter days will be analysed separately using Poisson regression. The primary outcome for objective 2 (cost-effectiveness) is the changes in costs relative to health benefits (incremental cost-effectiveness ratio) from adoption of the intervention.

Dissemination

Results will be disseminated via peer-reviewed journals and presentations at relevant conferences.A dissemination plan it being developed. Results will be published in the peer review literature, presented at relevant conferences and communicated via professional networks.

Link to publisher version (DOI)

http://dx.doi.org/10.1136/bmjopen-2017-018871

Peer Review

Before publication

Comments

Used by permission: the author(s).

Copyright © Brett Mitchell, Oyebola Fasugba, Anne Gardner, Jane Koerner, Peter Collignon, Allen Cheng, Nicholas Graves, Peter Morey, and Victoria Gregory 2017

Creative Commons License

Creative Commons Attribution-NonCommercial 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

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