Title

Quantitation of NAD+: Why Do We Need to Measure it?

Author Faculty (Discipline)

Nursing

Document Type

Article

Publication Date

12-2018

Early Online Version

7-23-2018

JOURNAL

Biochimica et Biophysica Acta (BBA) - General Subjects

VOLUME NUMBER

1862

ISSUE NUMBER

12

PAGE NUMBERS

2527-2532

ISSN

0304-4165

Embargo Period

1-22-2019

ANZSRC / FoR Code

111799 Public Health and Health Services not elsewhere classified| 119999 Medical and Health Sciences not elsewhere classified

Reportable Items (HERDC/ERA)

C1

Abstract

Background:

Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is currently investigated as an important target to extend lifespan and health span. Age-related NAD+ depletion due to the accumulation of oxidative stress is associated with reduced energy production, impaired DNA repair and genomic instability.

Scope of review: NAD+ levels can be elevated therapeutically using NAD+ precursors or through lifestyle modifications including exercise and caloric restriction. However, high amounts of NAD+ may be detrimental in cancer progression and may have deleterious immunogenic roles.

Major conclusions: Standardized quantitation of NAD+ and related metabolites may therefore represent an important component of NAD+ therapy.

General significance: Quantitation of NAD+ may serve dual roles not only as an ageing biomarker, but also as a diagnostic tool for the prevention of malignant disorders.

Link to publisher version (DOI)

https://doi.org/10.1016/j.bbagen.2018.07.023

Comments

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Copyright © 2018 Published by Elsevier B.V. All rights reserved


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