Title

Quantitation of NAD+: Why Do We Need to Measure it?

Author Faculty (Discipline)

Nursing

Document Type

Article

Publication Date

7-23-2018

Publication Details

This article was originally published as:

Liu, Y., Clement, J., Grant, R., Sachdev, P., & Braidy, N. (2018). Quantitation of NAD+: Why do we need to measure it? Biochimica et Biophysica Acta (BBA) - General Subjects, 1862(12), 2527-2532. doi: 10.1016/j.bbagen.2018.07.023

ISSN: 0304-4165

ANZSRC / FoR Code

111799 Public Health and Health Services not elsewhere classified| 119999 Medical and Health Sciences not elsewhere classified

Reportable Items

C1

Abstract

Background:

Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is currently investigated as an important target to extend lifespan and health span. Age-related NAD+ depletion due to the accumulation of oxidative stress is associated with reduced energy production, impaired DNA repair and genomic instability.

Scope of review: NAD+ levels can be elevated therapeutically using NAD+ precursors or through lifestyle modifications including exercise and caloric restriction. However, high amounts of NAD+ may be detrimental in cancer progression and may have deleterious immunogenic roles. Major conclusions: Standardized quantitation of NAD+ and related metabolites may therefore represent an important component of NAD+ therapy. General significance: Quantitation of NAD+ may serve dual roles not only as an ageing biomarker, but also as a diagnostic tool for the prevention of malignant disorders.

Comments

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Copyright © 2018 Published by Elsevier B.V. All rights reserved

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