Increased Fluid Intake for the Prevention of Urinary Tract Infection in Adults and Children in all Settings: A Systematic Review
Journal of Hospital Infection
ANZSRC / FoR Code
111001 Aged Care Nursing| 111003 Clinical Nursing: Secondary (Acute Care)| 111716 Preventive Medicine
Avondale Research Centre
Lifestyle and Health Research Centre
Non-antibiotic interventions for urinary tract infection (UTI) prevention have been investigated as a strategy to reduce antibiotic prescribing for UTI and subsequent antibiotic resistance. Increased hydration is widely advocated for preventing UTI; however, evidence for its effectiveness is unknown.
To systematically review the published literature on the effectiveness of increased fluid intake as a preventive intervention for UTI in adults and children in any setting.
Five electronic databases were searched from inception to February 2019 to identify published randomized controlled trials (RCTs) and quasi-experimental studies evaluating the effectiveness of high (≥1.5 L/24 h) versus normal/low (
Of the 2822 potentially relevant papers, two were eligible for inclusion: an RCT (individual randomization) and a cluster-RCT. Both studies differed regarding participants, setting, sample size, UTI definition, and intervention. The RCT was assessed as having a low risk of bias whereas the cluster-RCT had a high risk of bias. Only the RCT, which included healthy premenopausal women visiting primary care clinics, demonstrated statistical significance for the effect of high fluid intake for UTI prevention.
The lack of enough adequately powered and robust RCTs highlights the need for further research on the effectiveness of this intervention for UTI prevention.
Fasugba, O., Mitchell, B. G., McInnes, E., Koerner, J., Cheng, A. C., Cheng, H., & Middleton, S. (2019). Increased fluid intake for the prevention of urinary tract infection in adults and children in all settings: A systematic review. Journal of Hospital Infection, 104(1), 68-77. doi:10.1016/j.hin.2019.08.016