Author Faculty (Discipline)

Nursing

Document Type

Article

Publication Date

1-2021

Early Online Version

12-27-2020

JOURNAL

Antioxidants

VOLUME NUMBER

10

ISSUE NUMBER

1

PAGE NUMBERS

15

ISSN

2076-3921

Embargo Period

3-8-2021

ANZSRC / FoR Code

320599 Medical biochemistry and metabolomics not elsewhere classified

Avondale Research Centre

Lifestyle and Health Research Centre

Reportable Items (HERDC/ERA)

C1

Abstract

The significant increase in worldwide morbidity and mortality from non-communicable diseases (NCDs) indicates that the efficacy of existing strategies addressing this crisis may need improvement. Early identification of the metabolic irregularities associated with the disease process may be a key to developing early intervention strategies. Unhealthy lifestyle behaviours are well established drivers of the development of several NCDs, but the impact of such behaviours on health can vary considerably between individuals. How can it be determined if an individual’s unique set of lifestyle behaviours is producing disease? Accumulating evidence suggests that lifestyle-associated activation of oxidative and inflammatory processes is primary driver of the cell and tissue damage which underpins the development of NCDs. However, the benefit of monitoring subclinical inflammation and oxidative activity has not yet been established. After reviewing relevant studies in this context, we suggest that quantification of oxidative stress and inflammatory biomarkers during the disease-free prodromal stage of NCD development may have clinical relevance as a timely indicator of the presence of subclinical metabolic changes, in the individual, portending the development of disease. Monitoring markers of oxidative and inflammatory activity may therefore enable earlier and more efficient strategies to both prevent NCD development and/or monitor the effectiveness of treatment.

Link to publisher version (DOI)

https://doi.org/10.3390/antiox10010015

Peer Review

Before publication

Comments

Used by permission: the authors.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.


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