Title

Molecular Targets of Tannic Acid in Alzheimer's Disease

Author Faculty (Discipline)

Nursing

Document Type

Article

Publication Date

7-17-2017

JOURNAL

Current Alzheimer Research

VOLUME NUMBER

14

ISSUE NUMBER

8

PAGE NUMBERS

861-869

ISSN

1875-5828

Embargo Period

1-12-2021

ANZSRC / FoR Code

110999 Neurosciences not elsewhere classified

ANZSRC / FoR Code

420605 Preventative health care

Avondale Research Centre

Lifestyle and Health Research Centre

Reportable Items (HERDC/ERA)

C1

Abstract

Tannic acid (TA) is a naturally occurring plant-derived polyphenol found in several herbaceous and woody plants, including legumes, sorghum, beans, bananas, persimmons, raspberries, wines and a broad selection of teas. Clinically, TA has strong antioxidant/free radical scavenging, anti inflammatory, anti-viral/bacterial, and anti-carcinogenic properties. While the aetiology of Alzheimer’s disease (AD) remains unclear, this complex multifactorial neurodegenerative disorder remains the most common form of dementia, and is a growing public health concern worldwide. The neuroprotective effects of TA against AD have been shown in several in vitro and in vivo models of AD. Apart from its potent antioxidant and anti-inflammatory roles, evidence suggests that TA is also a natural inhibitor of β-secretase (BACE1) activity and protein expression. BACE1 is the primary enzyme responsible for the production and deposition of Aβ peptide. TA also destabilises neurotoxic amyloid beta (Aβ) fibrils in vitro. Apart from its effects on the Aβ cascade, TA can also inhibit the in vitro aggregation of tau peptide, a core component of intracellular neurofibrillary tangles (NFTs). This review summarizes the relevance of TA and TA-related vegetable extracts (tannins) in the pathogenesis of AD and its enzymatic targets. It also highlights the significance of TA as an important lead compound against AD.

Link to publisher version (DOI)

https://doi.org/10.2174/1567205014666170206163158

Peer Review

Before publication

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