Controlling Methicillin-Resistant Staphylococcus Aureus (MRSA) in a Hospital and the Role of Hydrogen Peroxide Decontamination: An Interrupted Time Series Analysis

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This article was originally published as:

Mitchell, B., Digney, W., Locket, P., & Dancer, S. (2014). Controlling methicillin-resistant Staphylococcus aureus (MRSA) in a hospital and the role of hydrogen perodoxide decontamination: An interrupted time series analysis. British Medical Journal Open, 4(4). doi: 10.1136/bmjopen-2013-004522

ISSN: 2044-6055


060502 Infectious Agents| 111099 Nursing not elsewhere classified| 111716 Preventive Medicine

Avondale Research Centre

Lifestyle Research Centre

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Objectives The impact of surface disinfection versus detergent cleaning on healthcare associated infection rates remains unresolved. We aimed to evaluate the efficacy of hydrogen peroxide (HP) decontamination against methicillin-resistant Staphylococcus aureus (MRSA).

Design Single centred retrospective before and after study design.

Setting Launceston General Hospital, Tasmania, Australia.

Participants Patients with MRSA infection or colonisation.

Interventions Rooms occupied by patients with MRSA infection or colonisation were cleaned following discharge with either detergent or HP.

Main outcome measures MRSA room contamination following cleaning; new MRSA acquisition in patients.

ResultsOver 3600 discharge cleans were completed, with more than 32 600 environmental swabs processed. MRSA was isolated from 24.7% rooms following detergent cleaning and from 18.8% of rooms after HP (p

Conclusions Use of HP disinfection led to a decrease in residual MRSA contamination in patient rooms compared with detergent. It may also have encouraged the reduction in patient MRSA acquisition despite several confounders including staff feedback on terminal cleaning, additional MRSA screening and quicker laboratory methods. Infection control is best served by concurrent interventions targeting both the patient and healthcare environment.


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