Five-Year Antimicrobial Resistance Patterns of Urinary Escherichia Coli at an Australian Tertiary Hospital: Time Series Analyses of Prevalence Data

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avondale-bepress-to-dspace.facultyNursing
avondale-bepress-to-dspace.licensehttp://creativecommons.org/licenses/by/4.0/
avondale-bepress-to-dspace.peer_review_statusPeer reviewed before publication
avondale-bepress.abstract<p>This study describes the antimicrobial resistance temporal trends and seasonal variation of<em> Escherichia coli </em>(<em>E</em>. <em>coli) </em>urinary tract infections (UTIs) over five years, from 2009 to 2013, and compares prevalence of resistance in hospital- and community-acquired <em>E</em>. <em>coli </em>UTI. A cross sectional study of <em>E</em>. <em>coli </em>UTIs from patients attending a tertiary referral hospital in Canberra, Australia was undertaken. Time series analysis was performed to illustrate resistance trends. Only the first positive <em>E</em>. <em>coli </em>UTI per patient per year was included in the analysis.</p> <p>A total of 15,022 positive cultures from 8724 patients were identified. Results are based on 5333 first <em>E</em>. <em>coli </em>UTIs, from 4732 patients, of which 84.2% were community acquired. Five-year hospital and community resistance rates were highest for ampicillin (41.9%) and trimethoprim (20.7%). Resistance was lowest for meropenem (0.0%), nitrofurantoin (2.7%), piperacillin-tazobactam (2.9%) and ciprofloxacin (6.5%). Resistance to amoxycillin-clavulanate, cefazolin, gentamicin and piperacillin-tazobactam were significantly higher in hospital- compared to community-acquired UTIs (9.3% versus 6.2%; 15.4% versus 9.7%; 5.2% versus 3.7% and 5.2% versus 2.5%, respectively). Trend analysis showed significant increases in resistance over five years for amoxycillin-clavulanate, trimethoprim, ciprofloxacin, nitrofurantoin, trimethoprim-sulphamethoxazole, cefazolin, ceftriaxone and gentamicin (P</p>
avondale-bepress.articleid1114
avondale-bepress.authorsOyebola Fasugba
avondale-bepress.authorsBrett G Mitchell
avondale-bepress.authorsGeorge Mnatzaganian
avondale-bepress.authorsAnindita Das
avondale-bepress.authorsPeter Collignon
avondale-bepress.authorsAnne Gardner
avondale-bepress.context-key9247521
avondale-bepress.coverpage-urlhttps://research.avondale.edu.au/nh_papers/113
avondale-bepress.document-typearticle
avondale-bepress.field.author_faculty_disciplineNursing
avondale-bepress.field.comments<p>Used by permission: the authors.</p>
avondale-bepress.field.custom_citation<p>Fasugba, O., Mitchell B. G., Mnatzaganian, G., Das, A., Collignon, P., & Gardner, A. (2016). Five-year antimicrobial resistance patterns of urinary Escherichia coli at an Australian Tertiary hospital: Time series analyses of prevalence data. <em>PLoS ONE, 11</em>(10), e0164306. doi:10.1371/journal.pone.0164306</p>
avondale-bepress.field.distribution_licensehttp://creativecommons.org/licenses/by/4.0/
avondale-bepress.field.doihttps://doi.org/10.1371/journal.pone.0164306
avondale-bepress.field.embargo_date2016-10-09T00:00:00Z
avondale-bepress.field.field_of_education06 Health
avondale-bepress.field.for060501 Bacteriology
avondale-bepress.field.issn1932-6203
avondale-bepress.field.issue_number10
avondale-bepress.field.journalPLoS ONE
avondale-bepress.field.page_numberse0164306
avondale-bepress.field.peer_reviewBefore publication
avondale-bepress.field.publication_date2016-10-06T00:00:00Z
avondale-bepress.field.reportable_itemsC1
avondale-bepress.field.research_centreLifestyle Research Centre
avondale-bepress.field.source_fulltext_urlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164306
avondale-bepress.field.source_publication<p>This article was originally published as:</p> <p>Fasugba, O., Mitchell B. G., Mnatzaganian, G., Das, A., Collignon, P., & Gardner, A. (2016). Five-year antimicrobial resistance patterns of urinary Escherichia coli at an Australian Tertiary hospital: Time series analyses of prevalence data. <em>PLoS ONE, 11</em>(10), 1-14. doi:10.1371/journal.pone.0164306</p> <p>ISSN: 1932-6203</p>
avondale-bepress.field.staff_classificationPermanent
avondale-bepress.field.volume_number11
avondale-bepress.fulltext-urlhttps://research.avondale.edu.au/cgi/viewcontent.cgi?article=1114&amp;context=nh_papers&amp;unstamped=1
avondale-bepress.keywordsantimicrobial resistance
avondale-bepress.keywordsantibiotic resistance
avondale-bepress.keywordsaustralia
avondale-bepress.keywordsurine
avondale-bepress.keywordsurinary
avondale-bepress.keywordsincidence
avondale-bepress.keywordsepidemiology
avondale-bepress.keywordsinfection
avondale-bepress.label113
avondale-bepress.publication-date2016-10-06T00:00:00Z
avondale-bepress.publication-titleNursing and Health Papers and Journal Articles
avondale-bepress.statepublished
avondale-bepress.submission-date2016-10-09T23:49:38Z
avondale-bepress.submission-pathnh_papers/113
avondale-bepress.titleFive-Year Antimicrobial Resistance Patterns of Urinary Escherichia Coli at an Australian Tertiary Hospital: Time Series Analyses of Prevalence Data
avondale-bepress.typearticle
dc.contributor.authorGardner, Anne
dc.contributor.authorCollignon, Peter
dc.contributor.authorDas, Anindita
dc.contributor.authorMnatzaganian, George
dc.contributor.authorMitchell, Brett G.
dc.contributor.authorFasugba, Oyebola
dc.date.accessioned2023-11-01T00:24:13Z
dc.date.available2023-11-01T00:24:13Z
dc.date.issued2016-10-06
dc.date.submitted2016-10-09T23:49:38Z
dc.description.abstract<p>This study describes the antimicrobial resistance temporal trends and seasonal variation of<em> Escherichia coli </em>(<em>E</em>. <em>coli) </em>urinary tract infections (UTIs) over five years, from 2009 to 2013, and compares prevalence of resistance in hospital- and community-acquired <em>E</em>. <em>coli </em>UTI. A cross sectional study of <em>E</em>. <em>coli </em>UTIs from patients attending a tertiary referral hospital in Canberra, Australia was undertaken. Time series analysis was performed to illustrate resistance trends. Only the first positive <em>E</em>. <em>coli </em>UTI per patient per year was included in the analysis.</p> <p>A total of 15,022 positive cultures from 8724 patients were identified. Results are based on 5333 first <em>E</em>. <em>coli </em>UTIs, from 4732 patients, of which 84.2% were community acquired. Five-year hospital and community resistance rates were highest for ampicillin (41.9%) and trimethoprim (20.7%). Resistance was lowest for meropenem (0.0%), nitrofurantoin (2.7%), piperacillin-tazobactam (2.9%) and ciprofloxacin (6.5%). Resistance to amoxycillin-clavulanate, cefazolin, gentamicin and piperacillin-tazobactam were significantly higher in hospital- compared to community-acquired UTIs (9.3% versus 6.2%; 15.4% versus 9.7%; 5.2% versus 3.7% and 5.2% versus 2.5%, respectively). Trend analysis showed significant increases in resistance over five years for amoxycillin-clavulanate, trimethoprim, ciprofloxacin, nitrofurantoin, trimethoprim-sulphamethoxazole, cefazolin, ceftriaxone and gentamicin (P</p>
dc.description.versionBefore publication
dc.identifier.citation<p>Fasugba, O., Mitchell B. G., Mnatzaganian, G., Das, A., Collignon, P., & Gardner, A. (2016). Five-year antimicrobial resistance patterns of urinary Escherichia coli at an Australian Tertiary hospital: Time series analyses of prevalence data. <em>PLoS ONE, 11</em>(10), e0164306. doi:10.1371/journal.pone.0164306</p>
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0164306
dc.identifier.issn1932-6203
dc.identifier.urihttps://research.avondale.edu.au/handle/123456789/09247521
dc.language.isoen_us
dc.provenance<p>This article was originally published as:</p> <p>Fasugba, O., Mitchell B. G., Mnatzaganian, G., Das, A., Collignon, P., & Gardner, A. (2016). Five-year antimicrobial resistance patterns of urinary Escherichia coli at an Australian Tertiary hospital: Time series analyses of prevalence data. <em>PLoS ONE, 11</em>(10), 1-14. doi:10.1371/journal.pone.0164306</p> <p>ISSN: 1932-6203</p>
dc.rights<p>Used by permission: the authors.</p>
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/
dc.subjectantimicrobial resistance
dc.subjectantibiotic resistance
dc.subjectaustralia
dc.subjecturine
dc.subjecturinary
dc.subjectincidence
dc.subjectepidemiology
dc.subjectinfection
dc.titleFive-Year Antimicrobial Resistance Patterns of Urinary Escherichia Coli at an Australian Tertiary Hospital: Time Series Analyses of Prevalence Data
dc.typeJournal Article
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