Effect of Maternal Iron Status on the Number of CD34+ Stem Cells Harvested from Umbilical Cord Blood

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avondale-bepress-to-dspace.facultyNursing
avondale-bepress-to-dspace.peer_review_statusPeer reviewed before publication
avondale-bepress.abstract<p><h4>Background</h4></p> <p>Hematopoietic progenitor cells (HPCs) from umbilical cord blood (UCB) are an alternative source of stem cells. However an adequate number of HPCs must be harvested from each UCB sample to make therapeutic applications possible. This study investigated the impact of selected maternal indices (in particular iron status) on the number of CD34+ cells collected in the UCB. <h4>Study Design and Methods</h4></p> <p>Blood samples were collected from 91 matched mother and umbilical cord pairs and analyzed for full blood count, iron status, and C-reactive protein. Viable CD34 enumeration was performed on the cord blood samples. <h4>Results</h4></p> <p>Low CD34+ cell counts were associated with higher maternal serum ferritin (SF), older mothers, lower UCB white blood cell count (WCC), lower UCB nucleated red blood cells (NRBCs), and lower birthweight. Maternal SF correlated with maternal variables of iron status and RBC indices, newborn weight, placental weight, and NRBCs/100 WCC. <h4>Conclusion</h4></p> <p>This study indicates that lower numbers of CD34+ cells are more likely to occur when collected from mothers with higher SF. This finding suggests that maternal SF and associated iron status play a significant, but as yet undefined, role in the generation of CD34+ cells in UCB.</p>
avondale-bepress.articleid1089
avondale-bepress.authorsBelinda Pope
avondale-bepress.authorsBevan Hokin
avondale-bepress.authorsRoss Grant
avondale-bepress.context-key7102192
avondale-bepress.coverpage-urlhttps://research.avondale.edu.au/nh_papers/88
avondale-bepress.document-typearticle
avondale-bepress.field.author_faculty_disciplineNursing
avondale-bepress.field.avon_earlyonline2014-03-25T00:00:00-07:00
avondale-bepress.field.comments<p>Due to copyright restrictions this article is unavailable for download.</p> <p>© 2014 AABB</p> <p>This article may be accessed from the publisher <a href="http://dx.doi.org/10.1111/trf.12547">here.</a></p> <p>At the time of writing <em>Ross Grant</em> was affiliated with <em>Avondale College of Higher Education</em> as a Conjoint Lecturer.</p>
avondale-bepress.field.custom_citation<p>Pope, B., Hokin, B., & Grant, R. (2014). Effect of maternal iron status on the number of CD34+ stem cells harvested from umbilical cord blood. <em>Transfusion, 54</em>(7), 1876–1880. doi:10.1111/trf.12547</p>
avondale-bepress.field.doihttps://doi.org/10.1111/trf.12547
avondale-bepress.field.email_boxtrue
avondale-bepress.field.embargo_date2015-05-13T00:00:00Z
avondale-bepress.field.field_of_education06 Health
avondale-bepress.field.for111499 Paediatrics and Reproductive Medicine not elsewhere classified
avondale-bepress.field.issn1537-2995
avondale-bepress.field.issue_number7
avondale-bepress.field.journalTransfusion
avondale-bepress.field.page_numbers1876-1880
avondale-bepress.field.peer_reviewBefore publication
avondale-bepress.field.publication_date2014-07-14T00:00:00Z
avondale-bepress.field.source_fulltext_urlhttps://doi.org/10.1111/trf.12547
avondale-bepress.field.source_publication<p>This article was originally published as:</p> <p>Pope, B., Hokin, B., & Grant, R. (2014). Effect of maternal iron status on the number of CD34+ stem cells harvested from umbilical cord blood. <em>Transfusion, 54</em>(7), 1876–1880. doi: 10.1111/trf.12547</p> <p>ISSN: 1537-2995</p>
avondale-bepress.field.staff_classificationPermanent
avondale-bepress.field.volume_number54
avondale-bepress.keywordscell transplant
avondale-bepress.label88
avondale-bepress.publication-date2014-07-14T00:00:00Z
avondale-bepress.publication-titleNursing and Health Papers and Journal Articles
avondale-bepress.statepublished
avondale-bepress.submission-date2015-05-13T19:29:46Z
avondale-bepress.submission-pathnh_papers/88
avondale-bepress.titleEffect of Maternal Iron Status on the Number of CD34+ Stem Cells Harvested from Umbilical Cord Blood
avondale-bepress.typearticle
dc.contributor.authorGrant, Ross
dc.contributor.authorHokin, Bevan
dc.contributor.authorPope, Belinda
dc.date.accessioned2023-11-01T00:22:37Z
dc.date.available2023-11-01T00:22:37Z
dc.date.issued2014-07-14
dc.date.submitted2015-05-13T19:29:46Z
dc.description.abstract<p><h4>Background</h4></p> <p>Hematopoietic progenitor cells (HPCs) from umbilical cord blood (UCB) are an alternative source of stem cells. However an adequate number of HPCs must be harvested from each UCB sample to make therapeutic applications possible. This study investigated the impact of selected maternal indices (in particular iron status) on the number of CD34+ cells collected in the UCB. <h4>Study Design and Methods</h4></p> <p>Blood samples were collected from 91 matched mother and umbilical cord pairs and analyzed for full blood count, iron status, and C-reactive protein. Viable CD34 enumeration was performed on the cord blood samples. <h4>Results</h4></p> <p>Low CD34+ cell counts were associated with higher maternal serum ferritin (SF), older mothers, lower UCB white blood cell count (WCC), lower UCB nucleated red blood cells (NRBCs), and lower birthweight. Maternal SF correlated with maternal variables of iron status and RBC indices, newborn weight, placental weight, and NRBCs/100 WCC. <h4>Conclusion</h4></p> <p>This study indicates that lower numbers of CD34+ cells are more likely to occur when collected from mothers with higher SF. This finding suggests that maternal SF and associated iron status play a significant, but as yet undefined, role in the generation of CD34+ cells in UCB.</p>
dc.description.versionBefore publication
dc.identifier.citation<p>Pope, B., Hokin, B., & Grant, R. (2014). Effect of maternal iron status on the number of CD34+ stem cells harvested from umbilical cord blood. <em>Transfusion, 54</em>(7), 1876–1880. doi:10.1111/trf.12547</p>
dc.identifier.doihttps://doi.org/10.1111/trf.12547
dc.identifier.issn1537-2995
dc.identifier.urihttps://research.avondale.edu.au/handle/123456789/07102192
dc.language.isoen_us
dc.provenance<p>This article was originally published as:</p> <p>Pope, B., Hokin, B., & Grant, R. (2014). Effect of maternal iron status on the number of CD34+ stem cells harvested from umbilical cord blood. <em>Transfusion, 54</em>(7), 1876–1880. doi: 10.1111/trf.12547</p> <p>ISSN: 1537-2995</p>
dc.rights<p>Due to copyright restrictions this article is unavailable for download.</p> <p>© 2014 AABB</p> <p>This article may be accessed from the publisher <a href="http://dx.doi.org/10.1111/trf.12547">here.</a></p> <p>At the time of writing <em>Ross Grant</em> was affiliated with <em>Avondale College of Higher Education</em> as a Conjoint Lecturer.</p>
dc.subjectcell transplant
dc.titleEffect of Maternal Iron Status on the Number of CD34+ Stem Cells Harvested from Umbilical Cord Blood
dc.typeJournal Article
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