Cerebrospinal Fluid Levels of Inflammation, Oxidative Stress and NAD+ are Linked to Differences in Plasma Carotenoid Concentrations

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avondale-bepress-to-dspace.facultyNursing
avondale-bepress-to-dspace.licensehttp://creativecommons.org/licenses/by/3.0/
avondale-bepress-to-dspace.peer_review_statusPeer reviewed before publication
avondale-bepress.abstract<p><strong>Background:</strong> The consumption of foods rich in carotenoids that possess significant antioxidant and inflammatory modulating properties has been linked to reduced risk of neuropathology. The objective of this study was to evaluate the relationship between plasma carotenoid concentrations and plasma and cerebrospinal fluid (CSF) markers of inflammation, oxidative stress and nicotinamide adenine dinucleotide (NAD+) in an essentially healthy human cohort.</p> <p><strong>Methods:</strong> Thirty-eight matched CSF and plasma samples were collected from consenting participants who required a spinal tap for the administration of anaesthetic. Plasma concentrations of carotenoids and both plasma and cerebrospinal fluid (CSF) levels of NAD(H) and markers of inflammation (IL-6, TNF-α) and oxidative stress (F2-isoprostanes, 8-OHdG and total antioxidant capacity) were quantified.</p> <p><strong>Results:</strong> The average age of participants was 53 years (SD = 20, interquartile range = 38). Both α-carotene (P = 0.01) and β-carotene (P < 0.001) correlated positively with plasma total antioxidant capacity. A positive correlation was observed between α-carotene and CSF TNF-α levels (P = 0.02). β-cryptoxanthin (P = 0.04) and lycopene (P = 0.02) inversely correlated with CSF and plasma IL-6 respectively. A positive correlation was also observed between lycopene and both plasma</p> <p>(P < 0.001) and CSF (P < 0.01) [NAD(H)]. Surprisingly no statistically significant associations were found between the most abundant carotenoids, lutein and zeaxanthin and either plasma or CSF markers of oxidative stress.</p> <p><strong>Conclusion:</strong> Together these findings suggest that consumption of carotenoids may modulate inflammation and enhance antioxidant defences within both the central nervous system (CNS) and systemic circulation. Increased levels of lycopene also appear to moderate decline in the essential pyridine nucleotide [NAD(H)] in both the plasma and the CSF.</p>
avondale-bepress.articleid1085
avondale-bepress.authorsJade Guest
avondale-bepress.authorsRoss Grant
avondale-bepress.authorsManohar Garg
avondale-bepress.authorsTrevor A Mori
avondale-bepress.authorsKevin D Croft
avondale-bepress.authorsAyse Bilgin
avondale-bepress.context-key6991670
avondale-bepress.coverpage-urlhttps://research.avondale.edu.au/nh_papers/83
avondale-bepress.document-typearticle
avondale-bepress.field.author_faculty_disciplineNursing
avondale-bepress.field.comments<p>Used by permission: the authors.</p> <p>At the time of writing <em>Ross Grant</em> was affiliated with Avondale College as a Conjoint Lecturer.</p>
avondale-bepress.field.custom_citation<p>Guest, J., Grant, R., Garg, M., Mori, T. A., Croft, K. D., & Bilgin, A. (2014). Cerebrospinal fluid levels of inflammation, oxidative stress and NAD+ are linked to differences in plasma carotenoid concentrations. <em>Journal of Neuroinflammation, 11</em>(1), 117. doi:10.1186/1742-2094-11-117</p>
avondale-bepress.field.distribution_licensehttp://creativecommons.org/licenses/by/3.0/
avondale-bepress.field.doihttps://doi.org/10.1186/1742-2094-11-117
avondale-bepress.field.embargo_date2015-04-15T00:00:00Z
avondale-bepress.field.field_of_education06 Health
avondale-bepress.field.for110999 Neurosciences not elsewhere classified
avondale-bepress.field.issn1742-2094
avondale-bepress.field.issue_number1
avondale-bepress.field.journalJournal of Neuroinflammation
avondale-bepress.field.page_numbers117
avondale-bepress.field.peer_reviewBefore publication
avondale-bepress.field.publication_date2014-07-01T00:00:00Z
avondale-bepress.field.reportable_itemsC1
avondale-bepress.field.source_publication<p>This article was originally published as:</p> <p>Guest, J., Grant, R., Garg, M., Mori, T. A., Croft, K. D., & Bilgin, A. (2014). Cerebrospinal fluid levels of inflammation, oxidative stress and NAD+ are linked to differences in plasma carotenoid concentrations. <em>Journal of Neuroinflammation, 11</em>(117), 1-10. doi:10.1186/1742-2094-11-117</p> <p>ISSN:1742-2094</p>
avondale-bepress.field.staff_classificationPermanent
avondale-bepress.field.volume_number11
avondale-bepress.fulltext-urlhttps://research.avondale.edu.au/cgi/viewcontent.cgi?article=1085&amp;context=nh_papers&amp;unstamped=1
avondale-bepress.keywordsbrain
avondale-bepress.keywordscarotenoid
avondale-bepress.keywordsinflammation
avondale-bepress.keywordsNAD+
avondale-bepress.keywordsoxidative stress
avondale-bepress.label83
avondale-bepress.publication-date2014-07-01T00:00:00Z
avondale-bepress.publication-titleNursing and Health Papers and Journal Articles
avondale-bepress.statepublished
avondale-bepress.submission-date2015-04-15T17:12:24Z
avondale-bepress.submission-pathnh_papers/83
avondale-bepress.titleCerebrospinal Fluid Levels of Inflammation, Oxidative Stress and NAD+ are Linked to Differences in Plasma Carotenoid Concentrations
avondale-bepress.typearticle
dc.contributor.authorBilgin, Ayse
dc.contributor.authorCroft, Kevin D.
dc.contributor.authorMori, Trevor A.
dc.contributor.authorGarg, Manohar
dc.contributor.authorGrant, Ross
dc.contributor.authorGuest, Jade
dc.date.accessioned2023-11-01T00:22:35Z
dc.date.available2023-11-01T00:22:35Z
dc.date.issued2014-07-01
dc.date.submitted2015-04-15T17:12:24Z
dc.description.abstract<p><strong>Background:</strong> The consumption of foods rich in carotenoids that possess significant antioxidant and inflammatory modulating properties has been linked to reduced risk of neuropathology. The objective of this study was to evaluate the relationship between plasma carotenoid concentrations and plasma and cerebrospinal fluid (CSF) markers of inflammation, oxidative stress and nicotinamide adenine dinucleotide (NAD+) in an essentially healthy human cohort.</p> <p><strong>Methods:</strong> Thirty-eight matched CSF and plasma samples were collected from consenting participants who required a spinal tap for the administration of anaesthetic. Plasma concentrations of carotenoids and both plasma and cerebrospinal fluid (CSF) levels of NAD(H) and markers of inflammation (IL-6, TNF-α) and oxidative stress (F2-isoprostanes, 8-OHdG and total antioxidant capacity) were quantified.</p> <p><strong>Results:</strong> The average age of participants was 53 years (SD = 20, interquartile range = 38). Both α-carotene (P = 0.01) and β-carotene (P < 0.001) correlated positively with plasma total antioxidant capacity. A positive correlation was observed between α-carotene and CSF TNF-α levels (P = 0.02). β-cryptoxanthin (P = 0.04) and lycopene (P = 0.02) inversely correlated with CSF and plasma IL-6 respectively. A positive correlation was also observed between lycopene and both plasma</p> <p>(P < 0.001) and CSF (P < 0.01) [NAD(H)]. Surprisingly no statistically significant associations were found between the most abundant carotenoids, lutein and zeaxanthin and either plasma or CSF markers of oxidative stress.</p> <p><strong>Conclusion:</strong> Together these findings suggest that consumption of carotenoids may modulate inflammation and enhance antioxidant defences within both the central nervous system (CNS) and systemic circulation. Increased levels of lycopene also appear to moderate decline in the essential pyridine nucleotide [NAD(H)] in both the plasma and the CSF.</p>
dc.description.versionBefore publication
dc.identifier.citation<p>Guest, J., Grant, R., Garg, M., Mori, T. A., Croft, K. D., & Bilgin, A. (2014). Cerebrospinal fluid levels of inflammation, oxidative stress and NAD+ are linked to differences in plasma carotenoid concentrations. <em>Journal of Neuroinflammation, 11</em>(1), 117. doi:10.1186/1742-2094-11-117</p>
dc.identifier.doihttps://doi.org/10.1186/1742-2094-11-117
dc.identifier.issn1742-2094
dc.identifier.urihttps://research.avondale.edu.au/handle/123456789/06991670
dc.language.isoen_us
dc.provenance<p>This article was originally published as:</p> <p>Guest, J., Grant, R., Garg, M., Mori, T. A., Croft, K. D., & Bilgin, A. (2014). Cerebrospinal fluid levels of inflammation, oxidative stress and NAD+ are linked to differences in plasma carotenoid concentrations. <em>Journal of Neuroinflammation, 11</em>(117), 1-10. doi:10.1186/1742-2094-11-117</p> <p>ISSN:1742-2094</p>
dc.rights<p>Used by permission: the authors.</p> <p>At the time of writing <em>Ross Grant</em> was affiliated with Avondale College as a Conjoint Lecturer.</p>
dc.rights.licensehttp://creativecommons.org/licenses/by/3.0/
dc.subjectbrain
dc.subjectcarotenoid
dc.subjectinflammation
dc.subjectNAD+
dc.subjectoxidative stress
dc.titleCerebrospinal Fluid Levels of Inflammation, Oxidative Stress and NAD+ are Linked to Differences in Plasma Carotenoid Concentrations
dc.typeJournal Article
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