Incidence of Antimicrobial Resistant Escherichia coli Urinary Tract Infections in the Australian Capital Territory

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avondale-bepress-to-dspace.facultyNursing
avondale-bepress.abstract<p>Introduction: The prevalence of antimicrobial resistance in urinary <em>Escherichia coli</em> <em>(E. coli)</em> is increasing in Australia but incidence and risk factors for resistance are not well described. We evaluated the incidence of antimicrobial resistant <em>E. coli</em> urinary tract infections (UTI) in a cohort of Australian Capital Territory (ACT) residents. The associations of age, gender and urine sample source with risk of resistant infections were also investigated.</p> <p>Methods: We utilised laboratory-based retrospective data from all ACT residents who submitted urine samples to ACT Pathology between January 2009 and December 2013.</p> <p>Results: A total of 146,915 urine samples from 57,837 ACT residents were identified over 5 years. The mean age of residents was 48 years (SD 26 years) with 64.4% female. The incidence of single drug resistant <em>E. coli</em> UTI was high for ampicillin, trimethoprim, and cefazolin (6.8%, 3.5%, and 1.9% respectively). No pandrug-resistant <em>E. coli</em> UTI was detected. Five year incidences of multi-drug and extensively drug-resistant <em>E.coli</em> UTI were 1.9% and 0.2% respectively. In multivariate logistic regressions, female age and sex over 38 years were significantly associated with single and multi-drug resistance. The risk of single-drug resistance was significantly higher in samples from after hours general practices compared to hospitals, office-hours general practices, community and specialist health services (adjusted odds ratio (OR) and 95% confidence intervals (CI) 2.6 (2.2-3.1)).</p> <p>Conclusions: In this study, incidence of multi-drug and extensively drug resistant <em>E.coli</em> UTI are low in comparison to international rates. Our findings have significant implications for antimicrobial prescribing.</p>
avondale-bepress.articleid1020
avondale-bepress.authorsOyebola Fasugba
avondale-bepress.authorsAnindita Das
avondale-bepress.authorsGeorge Mnatzaganian
avondale-bepress.authorsBrett G Mitchell
avondale-bepress.authorsPeter Collignon
avondale-bepress.authorsAnne Gardner
avondale-bepress.context-key11684689
avondale-bepress.coverpage-urlhttps://research.avondale.edu.au/nh_conferences/18
avondale-bepress.document-typeconference
avondale-bepress.field.author_faculty_disciplineNursing
avondale-bepress.field.comments<p>Due to copyright restrictions this conference paper abstract is unavailable for download.</p> <p>This abstract may be accessed from the publisher <a href="https://doi.org/10.1016/j.idh.2017.09.046">here.</a></p>
avondale-bepress.field.custom_citation<p>Fasugba, O., Das, A., Mnatzaganian, G., Mitchell, B. G., Collignon, P., & Gardner, A. (2017, November). <em>Incidence of antimicrobial resistant Escherichia coli urinary tract infections in the Australian Capital Territory.</em> Paper presented at the 6th International Australasian College for Infection Prevention and Control (ACIPC) Conference, Canberra, Australia. Abstract retrieved from https://doi.org/10.1016/j.idh.2017.09.046</p>
avondale-bepress.field.doihttps://doi.org/10.1016/j.idh.2017.09.046
avondale-bepress.field.embargo_date2018-03-01T00:00:00Z
avondale-bepress.field.for110309 Infectious Diseases
avondale-bepress.field.issn2468-0451
avondale-bepress.field.proceedings6th International Australasian College for Infection Prevention and Control (ACIPC) Conference
avondale-bepress.field.publication_date2017-11-01T00:00:00Z
avondale-bepress.field.reportable_itemsE5
avondale-bepress.field.source_publication<p>This conference abstract was originally published as:</p> <p>Fasugba, O., Das, A., Mnatzaganian, G., Mitchell, B. G., Collignon, P., & Gardner, A. (2017, November). <em>Incidence of antimicrobial resistant Escherichia coli urinary tract infections in the Australian Capital Territory.</em> Paper presented at the 6th International Australasian College for Infection Prevention and Control (ACIPC) Conference, Canberra, Australia. Abstract retrieved from https://doi.org/10.1016/j.idh.2017.09.046</p> <p>ISSN: 2468-0451</p>
avondale-bepress.keywordsurinary tract infections
avondale-bepress.keywordsAustralian Capital Territory
avondale-bepress.label18
avondale-bepress.publication-date2017-11-01T00:00:00Z
avondale-bepress.publication-titleNursing and Health Conference Papers
avondale-bepress.statepublished
avondale-bepress.submission-date2018-03-01T18:54:41Z
avondale-bepress.submission-pathnh_conferences/18
avondale-bepress.titleIncidence of Antimicrobial Resistant Escherichia coli Urinary Tract Infections in the Australian Capital Territory
avondale-bepress.typearticle
dc.contributor.authorGardner, Anne
dc.contributor.authorCollignon, Peter
dc.contributor.authorMitchell, Brett G.
dc.contributor.authorMnatzaganian, George
dc.contributor.authorDas, Anindita
dc.contributor.authorFasugba, Oyebola
dc.date.accessioned2023-11-01T00:26:12Z
dc.date.available2023-11-01T00:26:12Z
dc.date.issued2017-11-01
dc.date.submitted2018-03-01T18:54:41Z
dc.description.abstract<p>Introduction: The prevalence of antimicrobial resistance in urinary <em>Escherichia coli</em> <em>(E. coli)</em> is increasing in Australia but incidence and risk factors for resistance are not well described. We evaluated the incidence of antimicrobial resistant <em>E. coli</em> urinary tract infections (UTI) in a cohort of Australian Capital Territory (ACT) residents. The associations of age, gender and urine sample source with risk of resistant infections were also investigated.</p> <p>Methods: We utilised laboratory-based retrospective data from all ACT residents who submitted urine samples to ACT Pathology between January 2009 and December 2013.</p> <p>Results: A total of 146,915 urine samples from 57,837 ACT residents were identified over 5 years. The mean age of residents was 48 years (SD 26 years) with 64.4% female. The incidence of single drug resistant <em>E. coli</em> UTI was high for ampicillin, trimethoprim, and cefazolin (6.8%, 3.5%, and 1.9% respectively). No pandrug-resistant <em>E. coli</em> UTI was detected. Five year incidences of multi-drug and extensively drug-resistant <em>E.coli</em> UTI were 1.9% and 0.2% respectively. In multivariate logistic regressions, female age and sex over 38 years were significantly associated with single and multi-drug resistance. The risk of single-drug resistance was significantly higher in samples from after hours general practices compared to hospitals, office-hours general practices, community and specialist health services (adjusted odds ratio (OR) and 95% confidence intervals (CI) 2.6 (2.2-3.1)).</p> <p>Conclusions: In this study, incidence of multi-drug and extensively drug resistant <em>E.coli</em> UTI are low in comparison to international rates. Our findings have significant implications for antimicrobial prescribing.</p>
dc.identifier.citation<p>Fasugba, O., Das, A., Mnatzaganian, G., Mitchell, B. G., Collignon, P., & Gardner, A. (2017, November). <em>Incidence of antimicrobial resistant Escherichia coli urinary tract infections in the Australian Capital Territory.</em> Paper presented at the 6th International Australasian College for Infection Prevention and Control (ACIPC) Conference, Canberra, Australia. Abstract retrieved from https://doi.org/10.1016/j.idh.2017.09.046</p>
dc.identifier.doihttps://doi.org/10.1016/j.idh.2017.09.046
dc.identifier.issn2468-0451
dc.identifier.urihttps://research.avondale.edu.au/handle/123456789/11684689
dc.language.isoen_us
dc.provenance<p>This conference abstract was originally published as:</p> <p>Fasugba, O., Das, A., Mnatzaganian, G., Mitchell, B. G., Collignon, P., & Gardner, A. (2017, November). <em>Incidence of antimicrobial resistant Escherichia coli urinary tract infections in the Australian Capital Territory.</em> Paper presented at the 6th International Australasian College for Infection Prevention and Control (ACIPC) Conference, Canberra, Australia. Abstract retrieved from https://doi.org/10.1016/j.idh.2017.09.046</p> <p>ISSN: 2468-0451</p>
dc.rights<p>Due to copyright restrictions this conference paper abstract is unavailable for download.</p> <p>This abstract may be accessed from the publisher <a href="https://doi.org/10.1016/j.idh.2017.09.046">here.</a></p>
dc.subjecturinary tract infections
dc.subjectAustralian Capital Territory
dc.titleIncidence of Antimicrobial Resistant Escherichia coli Urinary Tract Infections in the Australian Capital Territory
dc.typeConference Publication
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