Significant Relationships Between a Simple Marker of Redox Balance and Lifestyle Behaviours; Relevance to the Framingham Risk Score

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avondale-bepress-to-dspace.facultyNursing
avondale-bepress-to-dspace.licensehttp://creativecommons.org/licenses/by/4.0/
avondale-bepress-to-dspace.peer_review_statusPeer reviewed before publication
avondale-bepress.abstract<p>Oxidative stress has been closely linked to the progressive cell damage associated with emerging non-communicable disease (NCDs). Early detection of these biochemical abnormalities before irreversible cell damage occurs may therefore be useful in identifying disease risk at an individual level. In order to test this hypothesis, this study assessed the relationship between a simple measure of redox status and lifestyle risk factors for NCDs, and the population-based risk score of Framingham. In a cross-sectional study design, 100 apparently healthy middle-aged males (n = 48) and females (n = 52) were asked to complete a comprehensive lifestyle assessment questionnaire, followed by body fat percentage and blood pressure measurements, and blood collection. The ratio of plasma total antioxidant capacity to hydroperoxide (TAC/HPX) was used as an index of redox balance. One-way ANOVA and multiple linear regression analysis were performed to analyse the association between TAC/HPX, lifestyle components and other plasma biomarkers. The TAC/HPX ratio was higher in males compared to females (t96 = 2.34, P = 0.021). TAC/HPX was also lower in participants with poor sleep quality (t93 = 2.39, P = 0.019), with high sleep apnoea risk (t62.2 = 3.32, P = 0.002), with high caffeine (F(2, 93) = 3.97, P = 0.022) and red meat intake (F(2, 93) = 5.55, P = 0.005). These associations were independent of gender. Furthermore, the TAC/HPX ratio decreased with increasing body fat percentage (F(2, 95) = 4.74, P = 0.011) and depression score (t94 = 2.38, P = 0.019), though these associations were dependent on gender. Importantly, a negative association was observed between TAC/HPX levels and the Framingham risk score in both males (r(45) = -0.39, P = 0.008) and females (r(50) = -0.33, P = 0.019) that was independent of other Framingham risk score components. Findings from this study suggests that a relatively simple measure of redox balance such as the TAC/HPX ratio may be a sensitive indicator of redox stress, and may therefore serve as a useful biomarker for assessing an individual’s specific NCD risk linked to unhealthy lifestyle practices.</p>
avondale-bepress.articleid1226
avondale-bepress.authorsNeda Seyed-Sadjadi
avondale-bepress.authorsJade Berg
avondale-bepress.authorsAyse A Bilgin
avondale-bepress.authorsChin Tung
avondale-bepress.authorsRoss Grant
avondale-bepress.context-key21064498
avondale-bepress.coverpage-urlhttps://research.avondale.edu.au/nh_papers/212
avondale-bepress.document-typearticle
avondale-bepress.field.author_faculty_disciplineNursing
avondale-bepress.field.comments<p>Used by permission: the author(s).</p>
avondale-bepress.field.custom_citation<p>Seyedsadjadi, N., Berg, J., Bilgin, A. A., Tung, C., & Grant, R. (2017). Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score. <em>PLoS ONE, 12</em>(11), e0187713. doi:10.1371/journal.pone.0187713</p>
avondale-bepress.field.distribution_licensehttp://creativecommons.org/licenses/by/4.0/
avondale-bepress.field.doihttps://doi.org/10.1371/journal.pone.0187713
avondale-bepress.field.embargo_date2021-01-12T00:00:00Z
avondale-bepress.field.field_of_education06 Health
avondale-bepress.field.for110199 Medical Biochemistry and Metabolomics not elsewhere classified
avondale-bepress.field.issn1932-6203
avondale-bepress.field.issue_number11
avondale-bepress.field.journalPLoS ONE
avondale-bepress.field.page_numberse0187713
avondale-bepress.field.peer_reviewBefore publication
avondale-bepress.field.publication_date2017-11-06T00:00:00Z
avondale-bepress.field.reportable_itemsC1
avondale-bepress.field.staff_classificationConjoint
avondale-bepress.field.volume_number12
avondale-bepress.fulltext-urlhttps://research.avondale.edu.au/cgi/viewcontent.cgi?article=1226&amp;context=nh_papers&amp;unstamped=1
avondale-bepress.keywordsredox balance
avondale-bepress.keywordslifestyle
avondale-bepress.keywordsFramingham
avondale-bepress.keywordsrisk score
avondale-bepress.label212
avondale-bepress.publication-date2017-11-06T00:00:00Z
avondale-bepress.publication-titleNursing and Health Papers and Journal Articles
avondale-bepress.statepublished
avondale-bepress.submission-date2021-01-12T16:26:35Z
avondale-bepress.submission-pathnh_papers/212
avondale-bepress.titleSignificant Relationships Between a Simple Marker of Redox Balance and Lifestyle Behaviours; Relevance to the Framingham Risk Score
avondale-bepress.typearticle
dc.contributor.authorGrant, Ross
dc.contributor.authorTung, Chin
dc.contributor.authorBilgin, Ayse A.
dc.contributor.authorBerg, Jade
dc.contributor.authorSeyed-Sadjadi, Neda
dc.date.accessioned2023-11-01T00:32:19Z
dc.date.available2023-11-01T00:32:19Z
dc.date.issued2017-11-06
dc.date.submitted2021-01-12T16:26:35Z
dc.description.abstract<p>Oxidative stress has been closely linked to the progressive cell damage associated with emerging non-communicable disease (NCDs). Early detection of these biochemical abnormalities before irreversible cell damage occurs may therefore be useful in identifying disease risk at an individual level. In order to test this hypothesis, this study assessed the relationship between a simple measure of redox status and lifestyle risk factors for NCDs, and the population-based risk score of Framingham. In a cross-sectional study design, 100 apparently healthy middle-aged males (n = 48) and females (n = 52) were asked to complete a comprehensive lifestyle assessment questionnaire, followed by body fat percentage and blood pressure measurements, and blood collection. The ratio of plasma total antioxidant capacity to hydroperoxide (TAC/HPX) was used as an index of redox balance. One-way ANOVA and multiple linear regression analysis were performed to analyse the association between TAC/HPX, lifestyle components and other plasma biomarkers. The TAC/HPX ratio was higher in males compared to females (t96 = 2.34, P = 0.021). TAC/HPX was also lower in participants with poor sleep quality (t93 = 2.39, P = 0.019), with high sleep apnoea risk (t62.2 = 3.32, P = 0.002), with high caffeine (F(2, 93) = 3.97, P = 0.022) and red meat intake (F(2, 93) = 5.55, P = 0.005). These associations were independent of gender. Furthermore, the TAC/HPX ratio decreased with increasing body fat percentage (F(2, 95) = 4.74, P = 0.011) and depression score (t94 = 2.38, P = 0.019), though these associations were dependent on gender. Importantly, a negative association was observed between TAC/HPX levels and the Framingham risk score in both males (r(45) = -0.39, P = 0.008) and females (r(50) = -0.33, P = 0.019) that was independent of other Framingham risk score components. Findings from this study suggests that a relatively simple measure of redox balance such as the TAC/HPX ratio may be a sensitive indicator of redox stress, and may therefore serve as a useful biomarker for assessing an individual’s specific NCD risk linked to unhealthy lifestyle practices.</p>
dc.description.versionBefore publication
dc.identifier.citation<p>Seyedsadjadi, N., Berg, J., Bilgin, A. A., Tung, C., & Grant, R. (2017). Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score. <em>PLoS ONE, 12</em>(11), e0187713. doi:10.1371/journal.pone.0187713</p>
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0187713
dc.identifier.issn1932-6203
dc.identifier.urihttps://research.avondale.edu.au/handle/123456789/21064498
dc.language.isoen_us
dc.rights<p>Used by permission: the author(s).</p>
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/
dc.subjectredox balance
dc.subjectlifestyle
dc.subjectFramingham
dc.subjectrisk score
dc.titleSignificant Relationships Between a Simple Marker of Redox Balance and Lifestyle Behaviours; Relevance to the Framingham Risk Score
dc.typeJournal Article
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